Botox

Botulinum Toxin Type A
Botulinumtoxin A consists of a heavy chain of 100-kilodalton and a light chain of 50-kilodalton making up the 150-kilodalton core type A molecule.

In motor neurons, the light chain of the BOTOX core molecule blocks the release of acetylcholine. When acetylcholine cannot be released, muscle contraction cannot occur.

Botulinum Toxin Type A
Injected directly into overactive muscles
Reduces contractions, relaxes muscles

BoNT as Therapeutic Agent in Neuromuscular Disorders
Purified BoNT/A = Botox®
Treat medical conditions characterized by muscle hyperactivity/spasm
Blepharospasm
Strabismus
Cervical dystonia
Glabellar lines
Spastic dystonia
Limb spasticity
Tremors
Chronic anal fissure
Hyperhidrosis.

Role of Botulinum Toxin in treatment of Headache
Dose: 25-30 units of Botulinum Toxin injected at multiple fixed symmetrical pericranial sites

• Frontalis
• Temporalis
• Corrugator
• Procerus muscles

BT relieves pain in 2 weeks from injection